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4.3 Antioxidant defense-related biomarkers 4.3.1 Nuclear factor E2-Related factor 2 (Nrf2) Nrf2 is a key transcription factor that regulates the expression of antioxidant genes, directly influencing a cells antioxidant capacity

Nanobiotechnology 20 (1), 216

Apart from being a proteogenic amino acid, thiol-containing cysteine is indispensable for synthesis of essential metabolites involved in a myriad of biological processes (Figure 1)

Laboratory work reported by Sikiric and colleagues indicates it remains stable in human gastric juice for more than 24 hours , a resilience that distinguishes it from the vast majority of peptides

4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production

For example, NCI has established a network of laboratories and a data center that could help identify biomarkers associated with the response to immunotherapy or treatment-related side effects